Housed within the Division of Biochemistry, Biophysics, & Structural Biology, the Biochemistry and Molecular Biology (BMB) emphasis is dedicated to the mechanistic understanding, at the molecular level, of essential processes for the life of the cell. To this end, the BMB emphasis uses rigorous and reductionist approaches to describe living systems in chemical and physical terms. Unique to BMB is the combination of powerful molecular biological methodologies (e.g. cloning, gene splicing and gene expression), with biochemical and biophysical assays, as well as structural biology strategies (e.g. X-ray crystallography, 2-D NMR, cryo-electron microscopy) for dissecting structure and function of macromolecules. Berkeley hosts unique, state-of-the-art facilities to carry out research using these methodologies.
The ability to understand complex biological processes by characterizing the activity of the molecular machinery governing processes such as DNA replication, transcription, transposition, recombination, protein synthesis, protein degradation and RNA processing, have greatly advanced our understanding of the living cell. Furthermore, these approaches and new knowledge are playing a major role in unraveling many complex biological processes at the organismal level, such as development, differentiation, mutagenesis, gene regulation, pathogenesis, oncogenesis, and aging.