Our society is increasingly relying on massive-scale computing systems in the cloud for all facets of life, from transportation and communication to business, governing, and scientific discovery. These applications are enabled by highly-parallel, warehouse-scale computing infrastructure operated by service providers like Amazon, Facebook, Microsoft and Google as well as other private and government entities. Designers of the next-generation of data intensive applications and warehouse-scale systems face enormous challenges, including improving performance, enabling greater programmer productivity, guaranteeing quality of service, using energy efficiently, provisioning power, maintaining reliability, controlling temperature, ensuring manageability, etc. In this research space, CSE faculty are pursuing the design of the hardware and software infrastructure for massive-scale computing systems. Major research topics include server architecture, hardware specialization, accelerators and general-purpose GPU computing, computational science, emerging memory technologies, data center physical infrastructure, distributed software and storage systems, virtualization, high-performance networking, and programming systems for cloud computing.