The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital.
The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.
A new era in medical intervention is on the horizon, enabled by revolutionary advances in genetics and genomics. The Human Genome Project has changed our approach to biology and medicine. As the power of the genome sequence became evident, technologies have also rapidly advanced, allowing acquiring sequence data from individuals at a phenomenal pace and increasingly lower costs. Massively parallel sequencing (also known as next-generation, or NextGen, sequencing) has ushered in the era of genomic and genetic medicine. Now, equipped with the patient's genome sequence, scientists can diagnose genetic disease, identify future disease risk, home in on disease modifiers, and predict drug responses.